2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130948B
    Thalidomide-4-O-C4-NH2 hydrochloride 2376990-29-1 99.35%
    Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-4-O-C4-NH2 hydrochloride
  • HY-126458
    Thalidomide-O-PEG2-propargyl 2098487-52-4 98.26%
    Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is an E3 ligase ligand-linker conjugate. Thalidomide-O-PEG2-propargyl is also a click chemistry reagent containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing an azide group.
    Thalidomide-O-PEG2-propargyl
  • HY-129703A
    Thalidomide-PEG2-C2-NH2 TFA 2097509-36-7 99.13%
    Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
    Thalidomide-PEG2-C2-NH2 TFA
  • HY-128716A
    Pomalidomide-PEG3-C2-NH2 TFA 2414913-97-4 99.0%
    Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs.
    Pomalidomide-PEG3-C2-NH2 TFA
  • HY-131159
    Thalidomide-O-C8-Boc 2225148-52-5
    Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-O-C8-Boc
  • HY-136163
    (S,R,S)-AHPC-C2-NH2 dihydrochloride 2341796-73-2 98.63%
    (S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.
    (S,R,S)-AHPC-C2-NH2 dihydrochloride
  • HY-138773
    Thalidomide-PEG5-COOH 2688100-28-7 99.49%
    Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-PEG5-COOH
  • HY-138778
    Thalidomide-Propargyne-PEG1-COOH 2828438-36-2 99.62%
    Thalidomide-Propargyne-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Propargyne-PEG1-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Thalidomide-Propargyne-PEG1-COOH
  • HY-138774
    Thalidomide-PEG4-COOH 2828438-28-2
    Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-PEG4-COOH
  • HY-149561
    Thalidomide-5-O-C4-NH2 hydrochloride 2694727-93-8 99.98%
    Thalidomide-5-O-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker.
    Thalidomide-5-O-C4-NH2 hydrochloride
  • HY-131886
    Pomalidomide 4'-alkylC4-acid 2225940-48-5 98.04%
    Pomalidomide 4'-alkylC4-acid (linker 16) is a E3 ligase ligand-linker conjugate. Pomalidomide 4'-alkylC4-acid contains a cereblon ligand, an alkylC4 chain, and a terminal acid. Pomalidomide 4'-alkylC4-acid can be used to couple with target protein ligands to synthesize PROTAC.
    Pomalidomide 4'-alkylC4-acid
  • HY-103614
    Thalidomide-O-amido-C8-NH2 TFA 1950635-16-1 99.43%
    Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-amido-C8-NH2 TFA
  • HY-103607
    (S,R,S)-AHPC-PEG2-C4-Cl 1835705-57-1 98.12%
    (S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
    (S,R,S)-AHPC-PEG2-C4-Cl
  • HY-136008
    (S,R,S)-AHPC-PEG1-NH2 2241641-57-4 98.48%
    (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG1-NH2
  • HY-132858
    Thalidomide-4-O-C10-COOH 2379870-45-6 99.14%
    Thalidomide-4-O-C10-COOH is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.
    Thalidomide-4-O-C10-COOH
  • HY-112618B
    Thalidomide-O-amido-C6-NH2 hydrochloride 2376990-31-5 99.32%
    Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
    Thalidomide-O-amido-C6-NH2 hydrochloride
  • HY-103608
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl 1835705-61-7 98.85%
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
  • HY-131866
    (S,R,S)-CO-C2-acid 2172819-72-4 98.0%
    (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand and linker conjugate, which can be used in the research and development of PROTACs.
    (S,R,S)-CO-C2-acid
  • HY-131890
    VH032 amide-PEG1-acid 2172820-07-2
    VH032 amide-PEG1-acid (Linker 10) is an E3 ligase ligand-linker conjugate comprising an E3 ligase ligand and a PEG1 linker terminated with a carboxylic acid group. VH032 amide-PEG1-acid can be used for the synthesis of CDK4/6-targeting PROTACs.
    VH032 amide-PEG1-acid
  • HY-167759
    Pomalidomide-PEG2-acetic acid 2143097-05-4 99.43%
    Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is the conjugate composed of a E3 ligase ligand and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis.
    Pomalidomide-PEG2-acetic acid
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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